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lüll Interleukin-33 and inflammatory bowel diseases: lessons from human studies Nunes T; Bernardazzi C; de Souza HSMediators Inflamm 2014[]; 2014 (ä): 423957Interleukin- (IL-) 33 is a widely expressed cytokine present in different cell types, such as epithelial, mesenchymal, and inflammatory cells, supporting a predominant role in innate immunity. IL-33 can function as a proinflammatory cytokine inducing Th2 type of immune response being involved with the defense against parasitic infections of the gastrointestinal tract. In addition, it has been proposed that IL-33 can act as a signaling molecule alerting the immune system of danger or tissue damage. Recently, in the intestinal mucosa, overexpression of IL-33 has been reported in samples from patients with inflammatory bowel diseases (IBD). This review highlights the available data regarding IL-33 in human IBD and discusses emerging roles for IL-33 as a key modulator of intestinal inflammation.|Animals[MESH]|Cytokines/metabolism[MESH]|Disease Models, Animal[MESH]|Humans[MESH]|Inflammation[MESH]|Inflammatory Bowel Diseases/*metabolism[MESH]|Interleukin-33[MESH]|Interleukins/*metabolism[MESH]|Intestinal Mucosa/immunology/metabolism[MESH]|Polymorphism, Genetic[MESH]|Signal Transduction[MESH]|Th2 Cells/cytology[MESH] |