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Trefoil factors in inflammatory bowel disease Aamann L; Vestergaard EM; Gronbaek HWorld J Gastroenterol 2014[Mar]; 20 (12): 3223-30Inflammatory bowel disease (IBD), which comprises ulcerative colitis and Crohn's disease, is characterized by inflammation of the gastrointestinal tract. The trefoil factors 1, 2, and 3 (TFF1-3) are a family of peptides that play important roles in the protection and repair of epithelial surfaces, including the gastrointestinal tract. TFFs may be involved in IBD pathogenesis and are a potential treatment option. In the present review, we describe the TFF family and their potential role in IBD by summarizing the current knowledge of their expression, possible function and pharmacological role in IBD.|*Gene Expression Regulation[MESH]|Animals[MESH]|Apoptosis[MESH]|Biomarkers/metabolism[MESH]|Colitis, Ulcerative/immunology/*metabolism[MESH]|Crohn Disease/immunology/*metabolism[MESH]|Genetic Variation[MESH]|Humans[MESH]|Inflammation[MESH]|Inflammatory Bowel Diseases/genetics/*metabolism[MESH]|Peptides/*metabolism[MESH]|Trefoil Factor-1[MESH]|Trefoil Factor-2[MESH]|Trefoil Factor-3[MESH]|Tumor Suppressor Proteins/metabolism[MESH] |
