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Serum soluble triggering receptor expressed on myeloid cells-1 and procalcitonin can reflect sepsis severity and predict prognosis: a prospective cohort study Li Z; Wang H; Liu J; Chen B; Li GMediators Inflamm 2014[]; 2014 (ä): 641039OBJECTIVE: To investigate the prognostic significance of serum soluble triggering receptor expressed on myeloid cells-1 (sTREM-1), procalcitonin (PCT), N-terminal probrain natriuretic peptide (NT-pro-BNP), C-reactive protein (CRP), cytokines, and clinical severity scores in patients with sepsis. METHODS: A total of 102 patients with sepsis were divided into survival group (n = 60) and nonsurvival group (n = 42) based on 28-day mortality. Serum levels of biomarkers and cytokines were measured on days 1, 3, and 5 after admission to an ICU, meanwhile the acute physiology and chronic health evaluation II (APACHE II) and sequential organ failure assessment (SOFA) scores were calculated. RESULTS: Serum sTREM-1, PCT, and IL-6 levels of patients in the nonsurvival group were significantly higher than those in the survival group on day 1 (P < 0.01). The area under a ROC curve for the prediction of 28 day mortality was 0.792 for PCT, 0.856 for sTREM-1, 0.953 for SOFA score, and 0.923 for APACHE II score. Multivariate logistic analysis showed that serum baseline sTREM-1 PCT levels and SOFA score were the independent predictors of 28-day mortality. Serum PCT, sTREM-1, and IL-6 levels showed a decrease trend over time in the survival group (P < 0.05). Serum NT-pro-BNP levels showed the predictive utility from days 3 and 5 (P < 0.05). CONCLUSION: In summary, elevated serum sTREM-1 and PCT levels provide superior prognostic accuracy to other biomarkers. Combination of serum sTREM-1 and PCT levels and SOFA score can offer the best powerful prognostic utility for sepsis mortality.|Adult[MESH]|Aged[MESH]|Biomarkers/blood[MESH]|C-Reactive Protein/metabolism[MESH]|Calcitonin Gene-Related Peptide[MESH]|Calcitonin/*blood[MESH]|Female[MESH]|Humans[MESH]|Intensive Care Units[MESH]|Interleukin-6/blood[MESH]|Male[MESH]|Membrane Glycoproteins/*blood[MESH]|Middle Aged[MESH]|Multivariate Analysis[MESH]|Natriuretic Peptide, Brain/blood[MESH]|Peptide Fragments/blood[MESH]|Prognosis[MESH]|Prospective Studies[MESH]|Protein Precursors/*blood[MESH]|ROC Curve[MESH]|Receptors, Immunologic/*blood[MESH]|Sepsis/*blood/*mortality[MESH]|Time Factors[MESH]|Treatment Outcome[MESH]|Triggering Receptor Expressed on Myeloid Cells-1[MESH] |
