Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
free
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
free free
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve Pubget Overpricing |
lüll Decreased activities of apolipoprotein m promoter are associated with the susceptibility to coronary artery diseases Zheng L; Luo G; Zhang J; Mu Q; Shi Y; Berggren-Soderlund M; Nilsson-Ehle P; Zhang X; Xu NInt J Med Sci 2014[]; 11 (4): 365-72The present study investigated the correlation among genetic polymorphisms of the proximal promoter region of apolipoprotein M (apoM) gene, the polymorphisms in relation to apoM expressions and the susceptibility to coronary artery diseases (CAD) in a Han Chinese population. Four common polymorphic sites, i.e., T-1628G, C-1065A, T-855C and T-778C, were confirmed, and a new deletion mutation C-724del was found, in 206 CAD patients and 209 non-CAD patients using direct DNA sequencing analyses. Occurrences of alleles T-1628G, T-855C and C-724del were significantly higher in CAD patients compared to non-CAD patients. Moreover we examined all these polymorphisms in relation to apoM expression by applying luciferase reporter assay. It demonstrated that constructs -855C and 724del showed obvious decreased luciferase activities, i.e., (0.93+/-0.15 vs. 2.11+/-0.15; P=0.012) and (1.13+/-0.25 vs. 2.11+/-0.15; P=0.009) respectively, which indicates these two polymorphisms could confer decreased apoM expressions. Meanwhile the occurrences of these two SNP were also significantly higher in the CAD patients than in non-CAD patients. It is therefore reasonable to speculate that down-regulated apoM expressions in relation to these polymorphisms may affect HDL and cholesterol metabolism in vivo and further influence the susceptibility to CAD, although the underlying mechanisms need further investigation.|Aged[MESH]|Apolipoproteins M[MESH]|Apolipoproteins/*genetics[MESH]|Cell Line[MESH]|Coronary Artery Disease/*genetics[MESH]|Female[MESH]|Genetic Predisposition to Disease/genetics[MESH]|Genotype[MESH]|Haplotypes/genetics[MESH]|Humans[MESH]|Lipocalins/*genetics[MESH]|Male[MESH]|Middle Aged[MESH]|Mutagenesis, Site-Directed[MESH]|Polymorphism, Single Nucleotide/genetics[MESH]|Promoter Regions, Genetic/*genetics[MESH]|Real-Time Polymerase Chain Reaction[MESH] |