Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
free
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
free free
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve Pubget Overpricing |
lüll Lynch syndrome from a surgeon perspective: retrospective study of clinical impact of mismatch repair protein expression analysis in colorectal cancer patients less than 50 years old Baiocchi GL; Portolani N; Vermi W; Baronchelli C; Gheza F; Zogno C; Scaglia A; Marchina E; Tiberio GA; Giulini SMBMC Surg 2014[Feb]; 14 (ä): 9BACKGROUND: In clinical practice, unexpected diagnosis of colorectal cancer in young patients requires prompt surgery, thus genetic testing for Lynch Syndrome is frequently missed, and clinical management may result incorrect. METHODS: Patients younger than 50 years old undergoing colorectal resection for cancer in the period 1994-2007 were identified (Group A, 49 cases), and compared to a group of randomly selected patients more than 50 (Group B, 85 cases). In 31 group A patients, immunohistochemical expression analysis of MLH1, MSH2 and MSH6 was performed; personal and familial history of patients with defective MMR proteins expression was further investigated, searching for synchronous and metachronous tumors in probands and their families. RESULTS: Fifty-one percent of patients did not express one or more MMR proteins (MMR-) and should be considered Lynch Syndrome carriers (16 patients, group A1); while only 31.2% of them were positive for Amsterdam criteria, 50% had almost another tumor, 37.5% had another colorectal tumor and 68% had relatives with colorectal tumor. This group of patients, compared with A2 group (< 50 years old, MMR+) and B group, showed typical characteristics of HNPCC, such as proximal location, mucinous histotype, poor differentiation, high stage and shorter survival. CONCLUSIONS: The present study confirms that preoperative knowledge of MMR proteins expression in colorectal cancer patients would allow correct staging, more extended colonic resection, specific follow-up and familial screening.|*Colectomy[MESH]|*Preoperative Care[MESH]|Adaptor Proteins, Signal Transducing/*metabolism[MESH]|Adult[MESH]|Age Factors[MESH]|Aged[MESH]|Aged, 80 and over[MESH]|Biomarkers, Tumor/*metabolism[MESH]|Colorectal Neoplasms, Hereditary Nonpolyposis/*diagnosis/genetics/metabolism/surgery[MESH]|Colorectal Neoplasms/diagnosis/genetics/metabolism/surgery[MESH]|DNA-Binding Proteins/*metabolism[MESH]|Diagnosis, Differential[MESH]|Female[MESH]|Follow-Up Studies[MESH]|Heterozygote[MESH]|Humans[MESH]|Immunohistochemistry[MESH]|Male[MESH]|Medical History Taking[MESH]|Middle Aged[MESH]|MutL Protein Homolog 1[MESH]|MutS Homolog 2 Protein/*metabolism[MESH]|Nuclear Proteins/*metabolism[MESH]|Retrospective Studies[MESH] |