Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
 free
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
 free
 free
 
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve
Pubget Overpricing |  
lüll
Network analysis reveals distinct clinical syndromes underlying acute mountain sickness Hall DP; MacCormick IJ; Phythian-Adams AT; Rzechorzek NM; Hope-Jones D; Cosens S; Jackson S; Bates MG; Collier DJ; Hume DA; Freeman T; Thompson AA; Baillie JKPLoS One 2014[]; 9 (1): e81229Acute mountain sickness (AMS) is a common problem among visitors at high altitude, and may progress to life-threatening pulmonary and cerebral oedema in a minority of cases. International consensus defines AMS as a constellation of subjective, non-specific symptoms. Specifically, headache, sleep disturbance, fatigue and dizziness are given equal diagnostic weighting. Different pathophysiological mechanisms are now thought to underlie headache and sleep disturbance during acute exposure to high altitude. Hence, these symptoms may not belong together as a single syndrome. Using a novel visual analogue scale (VAS), we sought to undertake a systematic exploration of the symptomatology of AMS using an unbiased, data-driven approach originally designed for analysis of gene expression. Symptom scores were collected from 292 subjects during 1110 subject-days at altitudes between 3650 m and 5200 m on Apex expeditions to Bolivia and Kilimanjaro. Three distinct patterns of symptoms were consistently identified. Although fatigue is a ubiquitous finding, sleep disturbance and headache are each commonly reported without the other. The commonest pattern of symptoms was sleep disturbance and fatigue, with little or no headache. In subjects reporting severe headache, 40% did not report sleep disturbance. Sleep disturbance correlates poorly with other symptoms of AMS (Mean Spearman correlation 0.25). These results challenge the accepted paradigm that AMS is a single disease process and describe at least two distinct syndromes following acute ascent to high altitude. This approach to analysing symptom patterns has potential utility in other clinical syndromes.|*Altitude[MESH]|*Mountaineering[MESH]|*Surveys and Questionnaires[MESH]|Acute Disease[MESH]|Adult[MESH]|Altitude Sickness/*diagnosis/etiology/prevention & control[MESH]|Antioxidants/administration & dosage[MESH]|Bolivia[MESH]|Expeditions[MESH]|Fatigue/complications[MESH]|Female[MESH]|Headache/complications[MESH]|Humans[MESH]|Male[MESH]|Piperazines/administration & dosage[MESH]|Purines/administration & dosage[MESH]|Severity of Illness Index[MESH]|Sildenafil Citrate[MESH]|Sleep Wake Disorders/complications[MESH]|Sulfones/administration & dosage[MESH]|Syndrome[MESH]|Tanzania[MESH]|Vasodilator Agents/administration & dosage[MESH]|Visual Analog Scale[MESH]|Young Adult[MESH] |
