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Anakinra for myocarditis in juvenile idiopathic arthritis Movva R; Brown SB; Morris DL; Figueredo VMTex Heart Inst J 2013[]; 40 (5): 623-5A 20-year-old pregnant woman with a history of juvenile idiopathic arthritis presented with flu-like symptoms, systemic inflammation with myocarditis, and severe cardiomyopathy. Six weeks earlier, her chronic-arthritis therapy had been changed from anakinra, an interleukin-1beta receptor antagonist, to etanercept. When she resumed taking anakinra, her condition improved dramatically, including a complete recovery of ventricular function. Myocarditis is a well-recognized complication of systemic vasculitides. This unusual case emphasizes the important pathophysiologic role of interleukin receptors in the successful treatment of myocarditis. We suggest that clinical cardiologists be aware of the therapeutic usefulness of biological agents such as anakinra in patients with rheumatic conditions.|*Pregnancy Complications, Cardiovascular[MESH]|Antirheumatic Agents/therapeutic use[MESH]|Arthritis, Juvenile/*complications/drug therapy[MESH]|Female[MESH]|Humans[MESH]|Interleukin 1 Receptor Antagonist Protein/*therapeutic use[MESH]|Myocarditis/*drug therapy/etiology[MESH]|Pregnancy[MESH]|Young Adult[MESH] |
