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lüll Downregulation of CD4+LAP+ and CD4+CD25+ regulatory T cells in acute coronary syndromes Lin YZ; Lu SH; Lu ZD; Huang Y; Shi Y; Liu L; Wang XY; Ji QWMediators Inflamm 2013[]; 2013 (ä): 764082BACKGROUND: Regulatory T (Treg) cells play a protective role in atherosclerosis prone models and are related to the onset of acute coronary syndromes (ACS, including non-ST-elevation ACS (NSTEACS) and ST-elevation acute myocardial infarction (STEAMI)). CD4+LAP+ Treg cells are a novel subset of Tregs that have been found to ameliorate atherosclerosis in ApoE(-/-) mice, and these cells also exist in humans. The present study was designed to investigate whether CD4+LAP+ Treg cells are involved in the onset of ACS. METHODS: The frequencies of CD4+LAP+ and CD4+CD25+ Treg cells were detected using flow cytometric analysis, and the plasma IL-10 and TGF- beta 1 levels were measured using an ELISA in 29 stable angina (SA) patients, 30 NSTEACS patients, 27 STEAMI patients, and a control group (30 cases). RESULTS: The results revealed a significant decrease in the frequencies of CD4+LAP+ and CD4+CD25+ Treg cells and in the levels of IL-10 and TGF- beta 1 in patients with ACS compared with those in the SA and control groups. CONCLUSIONS: The decrease in the frequencies of CD4+LAP+ and CD4+CD25+ Treg cells may play a role in the onset of ACS.|Acute Coronary Syndrome/*immunology/physiopathology[MESH]|Aged[MESH]|Down-Regulation[MESH]|Female[MESH]|Forkhead Transcription Factors/physiology[MESH]|Humans[MESH]|Interleukin-10/blood[MESH]|Male[MESH]|Middle Aged[MESH]|Peptides/*physiology[MESH]|Protein Precursors/*physiology[MESH]|T-Lymphocytes, Regulatory/*immunology[MESH]|Transforming Growth Factor beta/*physiology[MESH]|Transforming Growth Factor beta1/blood[MESH]|Ventricular Function, Left[MESH] |