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Interleukin-17: a promoter in colorectal cancer progression Wu D; Wu P; Huang Q; Liu Y; Ye J; Huang JClin Dev Immunol 2013[]; 2013 (ä): 436307It is widely accepted that chronic inflammation plays an active role in cancer. Inflammatory immunocytes and related cytokines in the tumor microenvironment are supposed to be a "double-edged sword" in colorectal cancer (CRC) initiation and progression. Interleukin-17 (IL-17), a pleiotropic proinflammatory cytokine, can promote cancer-elicited inflammation and prevent cancer cells from immune surveillance. Despite controversy, IL-17 is generally considered to be a promoter in CRC progression. In this review, we devote to summarize the current progress regarding the role of IL-17 in tumor initiation and progression, as well as the prognostic value in CRC.|Colorectal Neoplasms/*immunology/*metabolism/pathology[MESH]|Disease Progression[MESH]|Humans[MESH]|Interleukin-17/immunology/*metabolism[MESH]|Prognosis[MESH] |
