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lüll Lectin histochemistry in brains with juvenile form of neuronal ceroid-lipofuscinosis (Batten disease) Wisniewski KE; Maslinska DActa Neuropathol 1990[]; 80 (3): 274-9Defective utilization of dolichols in the synthesis of glycoprotein leads to an accumulation of the storage, pigment "ceroid" lipofuscin, containing high-mannose-type glycoconjugates, in brains affected by neuronal ceroid-lipofuscinoses (NCL). We have employed lectin histochemistry to study the distribution of such compounds and the composition of other glycoconjugates in brains of patients with a juvenile form of the disease (JNCL). Concanavalin A detected the high-mannose glycoconjugates in all neurons of brains with JNCL, in lipofuscin-containing neurons of aging brains and in some neurons of age-matched control brains. Three other lectins (soybean agglutinin, Peanut agglutinin and Ulex europaeus agglutinin-I) recognized sugar moieties in neurons containing lipofuscin in patients only with JNCL and not in age-matched or aging brains. The results led to the conclusion, that the binding pattern of these three lectins may differentiate between storage materials of NCL and aging brains.|*Lectins[MESH]|Adolescent[MESH]|Adult[MESH]|Aged[MESH]|Aging/metabolism[MESH]|Brain/*metabolism/pathology[MESH]|Child[MESH]|Histocytochemistry[MESH]|Humans[MESH]|Lipofuscin/metabolism[MESH]|Neuronal Ceroid-Lipofuscinoses/*metabolism/pathology[MESH]|Neurons/metabolism[MESH] |