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Differences in adjustment between individuals with alpha-1 antitrypsin deficiency (AATD)-associated COPD and non-AATD COPD Holm KE; Borson S; Sandhaus RA; Ford DW; Strange C; Bowler RP; Make BJ; Wamboldt FSCOPD 2013[Apr]; 10 (2): 226-34Smokers who have severe alpha-1 antitrypsin deficiency (AATD) are at risk for developing COPD earlier in life than smokers without AATD, and are likely to experience challenges adjusting to their illness because they are in a highly productive life stage when they are diagnosed with COPD. This study examined whether individuals with AATD-associated COPD differ from individuals with non-AATD COPD with regard to depression, anxiety, dyspnea, and health-related quality of life (HRQL). Cross-sectional data were collected via self-report questionnaires completed by 480 individuals with non-AATD COPD and 578 individuals with AATD-associated COPD under protocols with IRB approval. Multiple linear regression models were used to test whether individuals with non-AATD COPD differed from individuals with AATD-associated COPD with regard to depression, anxiety, dyspnea, and HRQL. All models adjusted for demographic and health characteristics. Individuals with AATD-associated COPD did not report more symptoms of depression or anxiety; however, they did report more dyspnea (B = 0.31, 95% CI = 0.16 to 0.47, p < 0.001) and impairment in HRQL (B = 4.75, 95% CI = 2.10 to 7.41, p < 0.001) than other individuals with COPD. Individuals with AATD-associated COPD were more likely to be a member of a couple (rather than single) and had a higher level of education when compared to individuals with non-AATD COPD. Resources available to persons with AATD-associated COPD, such as being in a serious relationship and having higher education, may offset the effect of age when considering symptoms of depression and anxiety in patients with COPD.|*Adaptation, Psychological[MESH]|Aged[MESH]|Anxiety/*etiology[MESH]|Cross-Sectional Studies[MESH]|Depression/*etiology[MESH]|Dyspnea/*etiology[MESH]|Female[MESH]|Humans[MESH]|Male[MESH]|Middle Aged[MESH]|Pulmonary Disease, Chronic Obstructive/*complications/physiopathology/psychology[MESH]|Quality of Life/psychology[MESH]|Smoking/adverse effects[MESH]|Surveys and Questionnaires[MESH]|alpha 1-Antitrypsin Deficiency/*complications/physiopathology/psychology[MESH] |
