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Modern concepts concerning the origin of the heartbeat Monfredi O; Maltsev VA; Lakatta EGPhysiology (Bethesda) 2013[Mar]; 28 (2): 74-92Physiological processes governing the heart beat have been under investigation for several hundred years. Major advances have been made in the recent past. A review of the present paradigm is presented here, including a look back at important steps that led us to where we are today, alongside a glimpse into the exciting future of pacemaker research.|Animals[MESH]|Biological Clocks/*physiology[MESH]|Heart Rate/*physiology[MESH]|Heart/*physiology[MESH]|Humans[MESH] |