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Changes in the management of benign liver tumours: an analysis of 285 patients Mezhir JJ; Fourman LT; Do RK; Denton B; Allen PJ; D'Angelica MI; DeMatteo RP; Fong Y; Jarnagin WRHPB (Oxford) 2013[Feb]; 15 (2): 156-63OBJECTIVES: Benign liver tumours (BLTs) are common and their management remains controversial. This study assesses the safety of a selective management approach. METHODS: Patients with BLT were identified from an institutional database. Patients with simple cysts or an incidental BLT in the setting of metastasis or concomitant malignancy were excluded. RESULTS: A total of 285 patients presenting during the period from January 1992 to December 2009 with haemangioma (53.0%), focal nodular hyperplasia (23.9%), adenoma (10.2%) or indeterminate/other lesions (13.0%) were evaluated. Of these, 117 patients (41.1%) underwent immediate resection and 168 patients (58.9%) were followed with serial imaging (median follow-up: 30 months). During observation, eight patients (4.8%) underwent resection for tumour growth, inability to exclude malignancy or symptoms; no patients demonstrated malignant transformation or tumour-related complications. During the study period, the number of BLTs evaluated and the proportion of patients observed increased from 129 BLTs of which 36.4% were observed in 1992-2002 to 156 BLTs of which 71.2% were observed in 2003-2009 (P < 0.001). Diagnostic uncertainty led to resection in 29.5% of patients during the earlier period, but in only 13.4% during the more recent 7 years (P < 0.05). CONCLUSIONS: Asymptomatic BLTs without concern for malignancy or adenoma can be safely observed with minimal risk for misdiagnosis. Patients selected for observation rarely require resection or develop tumour-related complications.|Adenoma, Liver Cell/diagnosis/surgery[MESH]|Adolescent[MESH]|Adult[MESH]|Aged[MESH]|Aged, 80 and over[MESH]|Algorithms[MESH]|Child[MESH]|Cysts/diagnosis/surgery[MESH]|Female[MESH]|Focal Nodular Hyperplasia/diagnosis/surgery[MESH]|Follow-Up Studies[MESH]|Hemangioma/diagnosis/surgery[MESH]|Humans[MESH]|Liver Diseases/*diagnosis/*surgery[MESH]|Liver Neoplasms/diagnosis/surgery[MESH]|Male[MESH]|Medical Records Systems, Computerized[MESH]|Middle Aged[MESH]|Prospective Studies[MESH]|Treatment Outcome[MESH] |
