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lüll Smooth muscle cell contraction increases the critical buckling pressure of arteries Hayman DM; Zhang J; Liu Q; Xiao Y; Han HCJ Biomech 2013[Feb]; 46 (4): 841-4Recent in vitro experiments demonstrated that arteries under increased internal pressure or decreased axial stretch may buckle into the tortuous pattern that is commonly observed in aging or diseased arteries in vivo. It suggests that buckling is a possible mechanism for the development of artery tortuosity. Vascular tone has significant effects on arterial mechanical properties but its effect on artery buckling is unknown. The objective of this study was to determine the effects of smooth muscle cell contraction on the critical buckling pressure of arteries. Porcine common carotid arteries were perfused in an ex vivo organ culture system overnight under physiological flow and pressure. The perfusion pressure was adjusted to determine the critical buckling pressure of these arteries at in vivo and reduced axial stretch ratios (1.5 and 1.3) at baseline and after smooth muscle contraction and relaxation stimulated by norepinephrine and sodium nitroprusside, respectively. Our results demonstrated that the critical buckling pressure was significantly higher when the smooth muscle was contracted compared with relaxed condition (97.3mmHg vs 72.9mmHg at axial stretch ratio of 1.3 and 93.7mmHg vs 58.6mmHg at 1.5, p<0.05). These results indicate that arterial smooth muscle cell contraction increased artery stability.|Animals[MESH]|Arteries/drug effects/*physiology[MESH]|Biomechanical Phenomena[MESH]|Blood Pressure/physiology[MESH]|Carotid Artery, Common/drug effects/physiology[MESH]|Muscle Contraction/drug effects/physiology[MESH]|Muscle, Smooth, Vascular/drug effects/*physiology[MESH]|Nitroprusside/pharmacology[MESH]|Norepinephrine/pharmacology[MESH]|Organ Culture Techniques[MESH]|Perfusion[MESH]|Sus scrofa[MESH]|Vasoconstriction/drug effects/physiology[MESH] |