Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
 free
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
 free
 free
 
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve
Pubget Overpricing |  
lüll
Risk factors for intrahepatic cholangiocarcinoma: association between metformin use and reduced cancer risk Chaiteerakij R; Yang JD; Harmsen WS; Slettedahl SW; Mettler TA; Fredericksen ZS; Kim WR; Gores GJ; Roberts RO; Olson JE; Therneau TM; Roberts LRHepatology 2013[Feb]; 57 (2): 648-55The associations between diabetes, smoking, obesity, and intrahepatic cholangiocarcinoma (ICC) risk remain inconclusive. Metformin is purportedly associated with a reduced risk for various cancers. This case-control study evaluated risk factors for ICC and explored the effects of metformin on ICC risk in a clinic/hospital-based cohort. ICC patients observed at the Mayo Clinic (Rochester, MN) between January 2000 and May 2010 were identified. Age, sex, ethnicity, and residential area-matched controls were selected from among Mayo Clinic Biobank participants. The associations between potential factors and ICC risk were determined. Six hundred and twelve cases and 594 controls were identified. Factors associated with increased ICC risk included biliary tract diseases (adjusted odds ratio [AOR]: 81.8; 95% confidence interval [CI]: 11.2-598.8; P < 0.001), cirrhosis (AOR, 8.0; 95% CI: 1.8-36.5; P = 0.007), diabetes (AOR, 3.6; 95% CI: 2.3-5.5; P < 0.001), and smoking (AOR, 1.6; 95% CI: 1.3-2.1; P < 0.001). Compared to diabetic patients not treated with metformin, the odds ratio (OR) for ICC for diabetic patients treated with metformin was significantly decreased (OR, 0.4; 95% CI: 0.2-0.9; P = 0.04). Obesity and metabolic syndrome were not associated with ICC. CONCLUSION: This study confirmed diabetes and smoking as independent risk factors for ICC. A novel finding was that treatment with metformin was significantly associated with a 60% reduction in ICC risk in diabetic patients.|Adult[MESH]|Aged[MESH]|Aged, 80 and over[MESH]|Bile Duct Neoplasms/etiology[MESH]|Bile Ducts, Intrahepatic[MESH]|Case-Control Studies[MESH]|Cholangiocarcinoma/*etiology/prevention & control[MESH]|Diabetes Complications/prevention & control[MESH]|Diabetes Mellitus/*drug therapy[MESH]|Female[MESH]|Humans[MESH]|Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use[MESH]|Hyperlipidemias/drug therapy[MESH]|Liver Neoplasms/*etiology/prevention & control[MESH]|Male[MESH]|Metformin/*therapeutic use[MESH]|Middle Aged[MESH]|Obesity/complications[MESH]|Regression Analysis[MESH]|Risk Factors[MESH]|Smoking/adverse effects[MESH] |
