Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
 free
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
 free
 free
 
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve
Pubget Overpricing |  
lüll
Perioperative heart-type fatty acid binding protein levels in atrial fibrillation after cardiac surgery Rader F; Pujara AC; Pattakos G; Rajeswaran J; Li L; Castel L; Chung MK; Gillinov AM; Costantini O; Van Wagoner DR; Blackstone EHHeart Rhythm 2013[Feb]; 10 (2): 153-7BACKGROUND: Postoperative atrial fibrillation (POAF) is common and associated with poor outcomes. Perioperative ischemia can alter arrhythmic substrate. OBJECTIVE: To demonstrate an association between perioperative measurements of heart-type fatty acid binding protein (HT-FABP), a sensitive marker of ischemic myocardial injury. METHODS: Blood samples from 63 inpatients undergoing coronary artery bypass surgery, valve surgery, or both were obtained before and up to 4 days after surgery. Continuous telemetry monitoring was used to detect POAF. Fifty-nine patients had at least 3 HT-FABP measurements. The relationship of enzyme-linked immunosorbent assay-measured HT-FABP with POAF was assessed by using joint logistic regression adjusted for age and surgery type. RESULTS: Thirty-five patients (55%) developed POAF; these were, on average, older (69.3+/-10 years vs 60+/-11 years; P = .0019), with a higher prevalence of heart failure (43% vs 17%; P = .034), chronic obstructive lung disease (26% vs 4%; P = .017), preoperative calcium channel blocker use (29% vs 7%; P = .031), and more likely to undergo combined surgery (21% vs 11%, P = .049). The joint age- and coronary artery bypass surgery-adjusted model revealed that postoperative but not preoperative HT-FABP levels predicted POAF (coefficient 1.9+/-0.87; P = .03). Longer bypass time, prior infarction, and worse renal function were all associated with higher postoperative HT-FABP. CONCLUSIONS: A greater rise of HT-FABP is associated with atrial fibrillation after cardiac surgery, suggesting that ischemic myocardial damage is a contributing underlying mechanism. Interventions that decrease perioperative ischemic injury may also decrease the occurrence of POAF.|Aged[MESH]|Atrial Fibrillation/*blood/diagnosis/mortality[MESH]|Biomarkers/metabolism[MESH]|Cohort Studies[MESH]|Coronary Artery Bypass/adverse effects/*methods[MESH]|Coronary Disease/*blood/diagnostic imaging/*surgery[MESH]|Enzyme-Linked Immunosorbent Assay[MESH]|Fatty Acid Binding Protein 3[MESH]|Fatty Acid-Binding Proteins/blood/*metabolism[MESH]|Follow-Up Studies[MESH]|Humans[MESH]|Logistic Models[MESH]|Middle Aged[MESH]|Postoperative Care/methods[MESH]|Postoperative Complications/blood/mortality[MESH]|Predictive Value of Tests[MESH]|Preoperative Care/methods[MESH]|Prospective Studies[MESH]|Radiography[MESH]|Risk Assessment[MESH]|Statistics, Nonparametric[MESH]|Survival Rate[MESH]|Treatment Outcome[MESH] |
