Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
free
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
free free
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve Pubget Overpricing |
lüll Reelin is involved in the crypt-villus unit homeostasis Garcia-Miranda P; Vazquez-Carretero MD; Sesma P; Peral MJ; Ilundain AATissue Eng Part A 2013[Jan]; 19 (1-2): 188-98Intestinal myofibroblasts secrete substances that control organogenesis and wound repair of the intestine. The myofibroblasts of the rat small intestine express reelin and the present work explores whether reelin regulates crypt-villus unit homeostasis using normal mice and mice with the reelin gene disrupted (reeler). The results reveal that mouse small intestine expresses reelin, its receptors apolipoprotein E receptor 2 (ApoER2) and very low-density lipoprotein receptor (VldlR) and the reelin effector protein Disabled-1 (Dab1) and that reelin expression is restricted to myofibroblasts. The absence of reelin significantly reduces epithelial cell proliferation, migration, and apoptosis and the number of Paneth cells. These effects are observed during the suckling, weaning, and adult periods. The number of Goblet cells is increased in the 2-month-old reeler mice. The absence of reelin also expands the extracellular space of the adherens junctions and desmosomes without significantly affecting either the tight-junction structure or the epithelial paracellular permeability. In conclusion, this is the first in vivo work showing that the absence of reelin alters intestinal epithelium homeostasis.|Animals[MESH]|Cell Adhesion Molecules, Neuronal/*metabolism[MESH]|Cells, Cultured[MESH]|Extracellular Matrix Proteins/*metabolism[MESH]|Homeostasis/*physiology[MESH]|Intestinal Mucosa/cytology/*metabolism[MESH]|Intestine, Small/cytology/*metabolism[MESH]|LDL-Receptor Related Proteins/*metabolism[MESH]|Male[MESH]|Mice[MESH]|Mice, Inbred C57BL[MESH]|Mice, Knockout[MESH]|Mice, Neurologic Mutants[MESH]|Myofibroblasts/*metabolism[MESH]|Nerve Tissue Proteins/*metabolism[MESH]|Receptors, LDL/metabolism[MESH]|Reelin Protein[MESH]|Serine Endopeptidases/*metabolism[MESH] |