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A novel oncogenic pathway by TLS-CHOP involving repression of MDA-7/IL-24 expression Oikawa K; Tanaka M; Itoh S; Takanashi M; Ozaki T; Muragaki Y; Kuroda MBr J Cancer 2012[Jun]; 106 (12): 1976-9BACKGROUND: Translocated in liposarcoma-CCAAT/enhancer binding protein homologous protein (TLS-CHOP) (also known as FUS-DDIT3) chimeric oncoprotein is found in the majority of human myxoid liposarcoma (MLS), but its molecular function remains unclear. METHODS: We knockdowned TLS-CHOP expression in MLS-derived cell lines by a specific small interfering RNA, and analysed the gene expression profiles with microarray. RESULTS: TLS-CHOP knockdown inhibited growth of MLS cells, and induced an anticancer cytokine, melanoma differentiation-associated gene 7 (MDA-7)/interleukin-24 (IL-24) expression. However, double knockdown of TLS-CHOP and MDA-7/IL-24 did not inhibit MLS cell growth. CONCLUSION: Repression of MDA-7/IL-24 expression by TLS-CHOP is required for MLS tumour growth, and TLS-CHOP may become a promising therapeutic target for MLS treatment.|Gene Expression[MESH]|Gene Expression Profiling[MESH]|Gene Knockdown Techniques[MESH]|Humans[MESH]|Interleukins/genetics/*metabolism[MESH]|Liposarcoma, Myxoid/genetics/*metabolism[MESH]|Oncogene Proteins, Fusion/genetics/*metabolism[MESH]|RNA-Binding Protein FUS/genetics/*metabolism[MESH]|Transcription Factor CHOP/genetics/*metabolism[MESH] |
