Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
 free
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
 free
 free
Warning: file_get_contents(http://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=22381432&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 445
 
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve
Pubget Overpricing |  
lüll
Electroanatomic remodeling of the left stellate ganglion after myocardial infarction Han S; Kobayashi K; Joung B; Piccirillo G; Maruyama M; Vinters HV; March K; Lin SF; Shen C; Fishbein MC; Chen PS; Chen LSJ Am Coll Cardiol 2012[Mar]; 59 (10): 954-61OBJECTIVES: The purpose of this study was to evaluate the changes of left stellate ganglionic nerve activity (SGNA) and left thoracic vagal nerve activity (VNA) after acute myocardial infarction (MI). BACKGROUND: Whether MI results in remodeling of extracardiac nerve activity remains unclear. METHODS: We implanted radiotransmitters to record the SGNA, VNA, and electrocardiogram in 9 ambulatory dogs. After baseline monitoring, MI was created by 1-h balloon occlusion of the coronary arteries. The dogs were then continuously monitored for 2 months. Both stellate ganglia were stained for growth-associated protein 43 and synaptophysin. The stellate ganglia from 5 normal dogs were used as control. RESULTS: MI increased 24-h integrated SGNA from 7.44 +/- 7.19 Ln(Vs)/day at baseline to 8.09 +/- 7.75 Ln(Vs)/day after the MI (p < 0.05). The 24-h integrated VNA before and after the MI was 5.29 +/- 5.04 Ln(Vs)/day and 5.58 +/- 5.15 Ln(Vs)/day, respectively (p < 0.05). A significant 24-h circadian variation was noted for the SGNA (p < 0.05) but not the VNA. The SGNA/VNA ratio also showed significant circadian variation. The nerve densities from the left SG were 63,218 +/- 34,719 mum(2)/mm(2) and 20,623 +/- 4,926 mum(2)/mm(2) for growth-associated protein 43 (p < 0.05) and were 32,116 +/- 8,190 mum(2)/mm(2)and 16,326 +/- 4,679 mum(2)/mm(2) for synaptophysin (p < 0.05) in MI and control groups, respectively. The right SG also showed increased nerve density after MI (p < 0.05). CONCLUSIONS: MI results in persistent increase in the synaptic density of bilateral stellate ganglia and is associated with increased SGNA and VNA. There is a circadian variation of the SGNA/VNA ratio. These data indicate significant remodeling of the extracardiac autonomic nerve activity and structures after MI.|Animals[MESH]|Disease Models, Animal[MESH]|Dogs[MESH]|Electrocardiography[MESH]|Heart Rate[MESH]|Male[MESH]|Monitoring, Physiologic/*methods[MESH]|Myocardial Infarction/pathology/*physiopathology[MESH]|Stellate Ganglion/*physiology[MESH]|Synaptic Transmission/physiology[MESH]|Vagus Nerve/*physiopathology[MESH] |
