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lüll Macrophage migration inhibitory factor (MIF): a key player in protozoan infections Rosado Jde D; Rodriguez-Sosa MInt J Biol Sci 2011[]; 7 (9): 1239-56Macrophage migration inhibitory factor (MIF) is a pleiotropic cytokine produced by the pituitary gland and multiple cell types, including macrophages (Mo), dendritic cells (DC) and T-cells. Upon releases MIF modulates the expression of several inflammatory molecules, such as TNF-alpha, nitric oxide and cyclooxygenase 2 (COX-2). These important MIF characteristics have prompted investigators to study its role in parasite infections. Several reports have demonstrated that MIF plays either a protective or deleterious role in the immune response to different pathogens. Here, we review the role of MIF in the host defense response to some important protozoan infections.|Animals[MESH]|Immunity, Innate/genetics/immunology[MESH]|Leishmania major/immunology/*pathogenicity[MESH]|Leishmaniasis/genetics/*immunology/*metabolism[MESH]|Macrophage Migration-Inhibitory Factors/genetics/*immunology/*metabolism[MESH]|Mice[MESH]|Receptors, Aryl Hydrocarbon/genetics/*metabolism[MESH] |