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Heme oxygenase-1 system and gastrointestinal inflammation: a short review Zhu X; Fan WG; Li DP; Kung H; Lin MCWorld J Gastroenterol 2011[Oct]; 17 (38): 4283-8Heme oxygenase-1 (HO-1) system catalyzes heme to biologically active products: carbon monoxide, biliverdin/bilirubin and free iron. It is involved in maintaining cellular homeostasis and many physiological and pathophysiological processes. A growing body of evidence indicates that HO-1 activation may play an important protective role in acute and chronic inflammation of gastrointestinal tract. This review focuses on the current understanding of the physiological significance of HO-1 induction and its possible roles in the gastrointestinal inflammation studied to date. The ability to upregulate HO-1 by pharmacological means or using gene therapy may offer therapeutic strategies for gastrointestinal inflammation in the future.|Animals[MESH]|Bilirubin/metabolism[MESH]|Biliverdine/metabolism[MESH]|Gastrointestinal Tract/*enzymology/*pathology[MESH]|Heme Oxygenase-1/genetics/*metabolism[MESH]|Humans[MESH]|Inflammation/*enzymology/*pathology[MESH]|Iron/metabolism[MESH]|Isoenzymes/genetics/metabolism[MESH]|Nitric Oxide Synthase Type II/metabolism[MESH]|Polymorphism, Genetic[MESH]|Promoter Regions, Genetic[MESH]|Up-Regulation[MESH] |
