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lüll Ochratoxin A in ruminants-A review on its degradation by gut microbes and effects on animals Mobashar M; Hummel J; Blank R; Sudekum KHToxins (Basel) 2010[Apr]; 2 (4): 809-39Ruminants are much less sensitive to ochratoxin A (OTA) than non-ruminants. The ruminal microbes, with protozoa being a central group, degrade the mycotoxin extensively, with disappearance half lives of 0.6-3.8 h. However, in some studies OTA was detected systemically when using sensitive analytical methods, probably due to some rumen bypass at proportions of estimated 2-6.5% of dosage (maximum 10%). High concentrate proportions and high feeding levels are dietary factors promoting the likeliness of systemic occurrence due to factors like shifts in microbial population and higher contamination potential. Among risk scenarios for ruminants, chronic intoxication represents the most relevant.|Animal Feed/analysis[MESH]|Animals[MESH]|Bacteria/*metabolism[MESH]|Diet[MESH]|Food Contamination/analysis[MESH]|Milk/metabolism[MESH]|Mycotoxins/*metabolism/toxicity[MESH]|Ochratoxins/analysis/*metabolism/toxicity[MESH]|Rumen/*microbiology[MESH]|Ruminants[MESH] |