Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
free
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
free free
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve Pubget Overpricing |
lüll Tetanus toxin C-fragment: the courier and the cure?Toivonen JM; Olivan S; Osta RToxins (Basel) 2010[Nov]; 2 (11): 2622-44In many neurological disorders strategies for a specific delivery of a biological activity from the periphery to the central nervous system (CNS) remains a considerable challenge for successful therapy. Reporter assays have established that the non-toxic C-fragment of tetanus toxin (TTC), provided either as protein or encoded by non-viral naked DNA plasmid, binds pre-synaptic motor neuron terminals and can facilitate the retrograde axonal transport of desired therapeutic molecules to the CNS. Alleviated symptoms in animal models of neurological diseases upon delivery of therapeutic molecules offer a hopeful prospect for TTC therapy. This review focuses on what has been learned on TTC-mediated neuronal targeting, and discusses the recent discovery that, instead of being merely a carrier molecule, TTC itself may well harbor neuroprotective properties.|Animals[MESH]|Axonal Transport/*drug effects[MESH]|Disease Models, Animal[MESH]|Gene Targeting[MESH]|Genetic Therapy[MESH]|Humans[MESH]|Molecular Targeted Therapy[MESH]|Motor Neuron Disease/drug therapy/genetics[MESH]|Motor Neurons/*drug effects[MESH]|Neural Pathways/*drug effects[MESH]|Neurodegenerative Diseases/drug therapy/genetics[MESH]|Neuromuscular Junction[MESH]|Neuroprotective Agents[MESH]|Peptide Fragments/genetics/*therapeutic use[MESH]|Presynaptic Terminals/*drug effects[MESH]|Tetanus Toxin/genetics/*therapeutic use[MESH] |