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lüll Antidiabetic effects of Vigna nakashimae extract in db/db mice Yeo JY; Ha TJ; Nam JS; Jung MHBiosci Biotechnol Biochem 2011[]; 75 (11): 2223-8The inhibitory activity of Vigna nakashimae extract against intestinal alpha-glucosidase was investigated in vitro and in vivo. The extract exerted a significant inhibitory effect against intestinal alpha-glucosidases. With sucrose-loading, it reduced the peak responses of blood glucose significantly in normal mice. Next, it was administrated to 8-week-old db/db mice for 2 weeks, and then plasma glucose, triglyceride, and total cholesterol levels were measured. The extract significantly suppressed postprandial hyperglycemia and blood glycated hemoglobin in the db/db mice. In addition, it lowered fasting glucose and improved glucose tolerance. Furthermore, it led to significant decreases in plasma triglyceride levels. It reduced endoplasmic reticulum stress in thapsigargin-induced HepG2 cells. Taken together, these results suggest that Vigna nakashimae extract has hypoglycemic and hypolipidemic effects that occur via inhibition of alpha-glucosidase activity and endoplasmic reticulum stress.|Animals[MESH]|Blood Glucose/*drug effects[MESH]|Cholesterol/blood[MESH]|Diabetes Mellitus, Experimental/*metabolism[MESH]|Fabaceae/*chemistry[MESH]|Fasting[MESH]|Glycoside Hydrolase Inhibitors[MESH]|Humans[MESH]|Hypoglycemic Agents/chemistry/*pharmacology[MESH]|Intestines/enzymology[MESH]|Mice[MESH]|Mice, Inbred Strains[MESH]|Plant Extracts/chemistry/*pharmacology[MESH]|Triglycerides/blood[MESH] |