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"The inflammasomes" Masumoto JNihon Rinsho Meneki Gakkai Kaishi 2011[]; 34 (5): 346-54Inflammation is a host adaptational response to cell injury caused by various exogenous and endogenous stimuli. IL-1beta, which is an important proinflammatory cytokine secreted at the site of cellular injury, plays an important role in inflammation. Inflammasome is an intracellular multi-protein complex that mediates caspase-1-dependent processing of IL-1beta. In this review, inflammasome function and its dysregulation are discussed in relation to autoinflammatory diseases.|Adaptor Proteins, Signal Transducing/physiology[MESH]|Apoptosis Regulatory Proteins/physiology[MESH]|CARD Signaling Adaptor Proteins/physiology[MESH]|Calcium-Binding Proteins/physiology[MESH]|Carrier Proteins/physiology[MESH]|Caspase 1/physiology[MESH]|Cytoskeletal Proteins/physiology[MESH]|DNA-Binding Proteins[MESH]|Hereditary Autoinflammatory Diseases/*etiology[MESH]|Humans[MESH]|Inflammasomes/chemistry/*physiology[MESH]|Inflammation Mediators[MESH]|Interleukin-1beta/*metabolism/physiology[MESH]|Intracellular Signaling Peptides and Proteins/physiology[MESH]|NLR Family, Pyrin Domain-Containing 3 Protein[MESH]|NLR Proteins[MESH]|Nuclear Proteins/physiology[MESH]|Pyrin[MESH] |
