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Radiofrequency ablation vs hepatic resection for solitary colorectal liver metastasis: a meta-analysis Wu YZ; Li B; Wang T; Wang SJ; Zhou YMWorld J Gastroenterol 2011[Sep]; 17 (36): 4143-8AIM: To evaluate the comparative therapeutic efficacy of radiofrequency ablation (RFA) and hepatic resection (HR) for solitary colorectal liver metastases (CLM). METHODS: A literature search was performed to identify comparative studies reporting outcomes for both RFA and HR for solitary CLM. Pooled odds ratios (OR) with 95% confidence intervals (95% CI) were calculated using either the fixed effects model or random effects model. RESULTS: Seven nonrandomized controlled trials studies were included in this analysis. These studies included a total of 847 patients: 273 treated with RFA and 574 treated with HR. The 5 years overall survival rates in the HR group were significantly better than those in the RFA group (OR: 0.41, 95% CI: 0.22-0.90, P = 0.008). RFA had a higher rate of local intrahepatic recurrence compared to HR (OR: 4.89, 95% CI: 1.73-13.87, P = 0.003). No differences were found between the two groups with respect to postoperative morbidity and mortality. CONCLUSION: HR was superior to RFA in the treatment of patients with solitary CLM. However, the findings have to be carefully interpreted due to the lower level of evidence.|Adult[MESH]|Aged[MESH]|Aged, 80 and over[MESH]|Catheter Ablation/*methods[MESH]|Clinical Trials as Topic[MESH]|Colorectal Neoplasms/*pathology[MESH]|Female[MESH]|Humans[MESH]|Liver Neoplasms/*secondary/*surgery[MESH]|Liver/*pathology/*surgery[MESH]|Male[MESH]|Middle Aged[MESH]|Treatment Outcome[MESH] |
