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lüll Ca(2+)-regulated ion channels Cox DHBMB Rep 2011[Oct]; 44 (10): 635-46Due to its high external and low internal concentration the Ca(2+) ion is used ubiquitously as an intracellular signaling molecule, and a great many Ca(2+)-sensing proteins have evolved to receive and propagate Ca(2+) signals. Among them are ion channel proteins, whose Ca(2+) sensitivity allows internal Ca(2+) to influence the electrical activity of cell membranes and to feedback-inhibit further Ca(2+) entry into the cytoplasm. In this review I will describe what is understood about the Ca(2+) sensing mechanisms of the three best studied classes of Ca(2+)-sensitive ion channels: Large-conductance Ca(2+)-activated K(+) channels, small-conductance Ca(2+)-activated K(+) channels, and voltage- gated Ca(2+) channels. Great strides in mechanistic understanding have be made for each of these channel types in just the past few years.|Calcium/*metabolism[MESH]|Cell Membrane/metabolism[MESH]|Ion Channel Gating/physiology[MESH]|Ion Channels/*metabolism[MESH]|Membrane Potentials/physiology[MESH]|Potassium/metabolism[MESH] |