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Looking to the future: biomarkers in the management of pancreatic adenocarcinoma Spratlin JL; Mulder KEInt J Mol Sci 2011[]; 12 (9): 5895-907The incidence and mortality of pancreas cancer converge. There has been little advancement in the treatment of pancreas cancer since the acceptance of gemcitabine as the standard therapy. Unfortunately, the efficacy of gemcitabine is dismal. While there is much discussion for the development of biomarkers to help direct therapy in this area, there is little action to move them into clinical practice. Herein, we review potential pancreatic cancer biomarkers and discuss the limitations in their implementation.|Adenocarcinoma/diagnosis/*drug therapy/metabolism[MESH]|Antimetabolites, Antineoplastic/*therapeutic use[MESH]|Biomarkers, Tumor/*metabolism[MESH]|Humans[MESH]|Outcome Assessment, Health Care/methods[MESH]|Pancreatic Neoplasms/diagnosis/*drug therapy/metabolism[MESH]|Reproducibility of Results[MESH]|Sensitivity and Specificity[MESH] |
