Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
free
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
free free
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve Pubget Overpricing |
lüll MicroRNAs, an active and versatile group in cancers Liu J; Zheng M; Tang YL; Liang XH; Yang QInt J Oral Sci 2011[Oct]; 3 (4): 165-75microRNAs (miRNAs) are a class of non-coding RNAs that function as endogenous triggers of the RNA interference pathway. Studies have shown that thousands of human protein-coding genes are regulated by miRNAs, indicating that miRNAs are master regulators of many important biological processes, such as cancer development. miRNAs frequently have deregulated expression in many types of human cancers, and play critical roles in tumorigenesis, which functions either as tumor suppressors or as oncogenes. Recent studies have shown that miRNAs are highly related with cancer progression, including initiating, growth, apoptosis, invasion, and metastasis. Furthermore, miRNAs are shown to be responsible for the cancer-related inflammation, anti-cancer drug resistance, and regulation of cancer stem cells. Therefore, miRNAs have generated great interest as a novel strategy in cancer diagnosis and therapy. Here we review the versatile roles of miRNAs in cancers and their potential applications for diagnosis, prognosis, and treatment as biomarkers.|*Gene Expression Regulation, Neoplastic[MESH]|Animals[MESH]|Biomarkers, Tumor[MESH]|Drug Resistance, Neoplasm/genetics[MESH]|Epithelial-Mesenchymal Transition/genetics[MESH]|Gene Knockdown Techniques[MESH]|Genes, Tumor Suppressor[MESH]|Humans[MESH]|Inflammation/genetics[MESH]|MicroRNAs/*genetics/*physiology[MESH]|Neoplasm Invasiveness/genetics[MESH]|Neoplasm Metastasis/genetics[MESH]|Neoplastic Stem Cells/metabolism[MESH]|Oncogenes/genetics[MESH] |