Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
free
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
free free
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve Pubget Overpricing |
lüll Hepatitis C virus infection: molecular pathways to insulin resistance Parvaiz F; Manzoor S; Tariq H; Javed F; Fatima K; Qadri IVirol J 2011[Oct]; 8 (ä): 474Chronic Hepatitis C virus has the potential of inducing insulin resistance and type 2 Diabetes Mellitus in vitro as well as in vivo . Structural and non-structural proteins of HCV modulate cellular gene expression in such a way that insulin signaling is hampered, concomitantly leads toward diabetes mellitus. A number of mechanisms have been proposed in regard to the HCV induced insulin resistance involving the upregulation of Inflammatory cytokine TNF-alpha, hypophosphorylation of IRS-1 and IRS-2, phosphorylation of Akt, up-regulation of gluconeogenic genes, accumulation of lipids and targeting lipid storage organelles. This review provides an insight of molecular mechanisms by which HCV structural and non-structural proteins can induce insulin resistance.|*Gene Expression Regulation[MESH]|*Insulin Resistance[MESH]|*Signal Transduction[MESH]|Animals[MESH]|Diabetes Mellitus, Type 2/etiology/*metabolism/physiopathology/virology[MESH]|Gluconeogenesis[MESH]|Glucose/metabolism[MESH]|Hepacivirus/genetics/*metabolism[MESH]|Hepatitis C, Chronic/complications/*metabolism/physiopathology/virology[MESH]|Humans[MESH]|Insulin Receptor Substrate Proteins/genetics/metabolism[MESH]|Insulin/metabolism[MESH]|Lipogenesis[MESH]|Mice[MESH]|Mice, Transgenic[MESH]|Phosphorylation[MESH]|Proto-Oncogene Proteins c-akt/genetics/metabolism[MESH]|Tumor Necrosis Factor-alpha/biosynthesis[MESH]|Viral Nonstructural Proteins/genetics/*metabolism[MESH]|Viral Structural Proteins/genetics/*metabolism[MESH] |