Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
 free
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
 free
 free
 
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve
Pubget Overpricing |  
lüll
Dengue virus and autophagy Heaton NS; Randall GViruses 2011[Aug]; 3 (8): 1332-41Several independent groups have published that autophagy is required for optimal RNA replication of dengue virus (DENV). Initially, it was postulated that autophagosomes might play a structural role in replication complex formation. However, cryo-EM tomography of DENV replication complexes showed that DENV replicates on endoplasmic reticulum (ER) cisternae invaginations and not on classical autophagosomes. Recently, it was reported that autophagy plays an indirect role in DENV replication by modulating cellular lipid metabolism. DENV-induced autophagosomes deplete cellular triglycerides that are stored in lipid droplets, leading to increased beta-oxidation and energy production. This is the first example of a virus triggering autophagy to modulate cellular physiology. In this review, we summarize these data and discuss new questions and implications for autophagy during DENV replication.|*Autophagy[MESH]|Cell Line[MESH]|Cryoelectron Microscopy[MESH]|Dengue Virus/genetics/*pathogenicity/physiology[MESH]|Dengue/*virology[MESH]|Endoplasmic Reticulum/metabolism/virology[MESH]|Hepatocytes/metabolism/virology[MESH]|Humans[MESH]|Lipid Metabolism[MESH]|Oxidation-Reduction[MESH]|Phagosomes/metabolism[MESH]|RNA, Viral/genetics/metabolism[MESH]|Viral Proteins/genetics/metabolism[MESH]|Virus Replication[MESH] |
