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lüll Viruses, autophagy genes, and Crohn s disease Hubbard VM; Cadwell KViruses 2011[Jul]; 3 (7): 1281-311The etiology of the intestinal disease Crohn's disease involves genetic factors as well as ill-defined environmental agents. Several genetic variants linked to this disease are associated with autophagy, a process that is critical for proper responses to viral infections. While a role for viruses in this disease remains speculative, accumulating evidence indicate that this possibility requires serious consideration. In this review, we will examine the three-way relationship between viruses, autophagy genes, and Crohn's disease and discuss how host-pathogen interactions can mediate complex inflammatory disorders.|Animals[MESH]|Autophagy/*genetics[MESH]|Crohn Disease/*genetics/pathology/*virology[MESH]|Genetic Predisposition to Disease[MESH]|Humans[MESH]|Immunity, Mucosal/genetics/immunology[MESH] |