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RIG-I like receptors in antiviral immunity and therapeutic applications Ireton RC; Gale M JrViruses 2011[Jun]; 3 (6): 906-19The RNA helicase family of RIG-I-like receptors (RLRs) is a key component of host defense mechanisms responsible for detecting viruses and triggering innate immune signaling cascades to control viral replication and dissemination. As cytoplasm-based sensors, RLRs recognize foreign RNA in the cell and activate a cascade of antiviral responses including the induction of type I interferons, inflammasome activation, and expression of proinflammatory cytokines and chemokines. This review provides a brief overview of RLR function, ligand interactions, and downstream signaling events with an expanded discussion on the therapeutic potential of targeting RLRs for immune stimulation and treatment of virus infection.|*Immunity, Innate[MESH]|Animals[MESH]|Antiviral Agents/therapeutic use[MESH]|DEAD-box RNA Helicases/genetics/*immunology[MESH]|Enzyme Activators/therapeutic use[MESH]|Humans[MESH]|Virus Diseases/drug therapy/*enzymology/*immunology/virology[MESH]|Virus Physiological Phenomena[MESH]|Viruses/drug effects[MESH] |
