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lüll Revolutionary change in rheumatoid arthritis management with biological therapy Takeuchi TKeio J Med 2011[]; 60 (3): 75-81Biological agents targeting a specific molecule have extraordinarily fine specificity and powerful functional capabilities. By the introduction of biological therapy, management of rheumatoid arthritis has undergone a revolution and a paradigm shift. In this review, I will summarize the role in the pathogenesis of rheumatoid arthritis of the molecules targeted by biological agents. Providing evidence obtained in clinical trials and investigator-initiated clinical studies in Japan, the effectiveness and safety of biological therapy in rheumatoid arthritis are discussed. Finally, studies aiming at a personalized strategy with biological agents are listed and the future perspectives toward tailor-made medicine in the field of rheumatology are discussed.|*Biological Therapy[MESH]|Animals[MESH]|Antibodies, Monoclonal/adverse effects/pharmacology/therapeutic use[MESH]|Antirheumatic Agents/adverse effects/pharmacology/therapeutic use[MESH]|Arthritis, Rheumatoid/*drug therapy/pathology/physiopathology[MESH]|Clinical Trials as Topic[MESH]|Etanercept[MESH]|Humans[MESH]|Immunoglobulin G/adverse effects/pharmacology/therapeutic use[MESH]|Molecular Targeted Therapy[MESH]|Receptors, Tumor Necrosis Factor/therapeutic use[MESH]|Treatment Outcome[MESH]|Tumor Necrosis Factor-alpha/*antagonists & inhibitors[MESH] |