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Hepatic and renal manifestations in autosomal dominant polycystic kidney disease: a dichotomy of two ends of a spectrum van Gulick JJ; Gevers TJ; van Keimpema L; Drenth JPNeth J Med 2011[Sep]; 69 (9): 367-71Autosomal dominant polycystic kidney disease (ADPKD) is a multisystem disorder. It is the most common genetic cause of end-stage renal disease. One frequent extra-renal manifestation is hepatic cyst formation. The majority of ADPKD patients develop complications as a result of renal cyst formation; however, a small proportion develop extensive hepatic disease with minor renal features. Both phenotypes seem to represent the spectrum of ADPKD. This review discusses the current understanding of the pathogenesis of the disease, its manifestations and the mechanisms of cyst formation. Furthermore, it focuses on monitoring the disease and the treatment options currently available.|Humans[MESH]|Hypertension/etiology[MESH]|Kidney Failure, Chronic/*etiology[MESH]|Liver Diseases/*etiology/therapy[MESH]|Polycystic Kidney, Autosomal Dominant/*complications/diagnosis/genetics/therapy[MESH] |
