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lüll Structural analysis of hubs in human NR-RTK network Choura M; Rebai ABiol Direct 2011[Oct]; 6 (ä): 49BACKGROUND: Currently a huge amount of protein-protein interaction data is available therefore extracting meaningful ones are a challenging task. In a protein-protein interaction network, hubs are considered as key proteins maintaining function and stability of the network. Therefore, studying protein-protein complexes from a structural perspective provides valuable information for predicted interactions. RESULTS: In this study, we have predicted by comparative modelling and docking methods protein-protein complexes of hubs of human NR-RTK network inferred from our earlier study. We found that some interactions are mutually excluded while others could occur simultaneously. This study revealed by structural analysis the key role played by Estrogen receptor (ESR1) in mediating the signal transduction between human Receptor Tyrosine kinases (RTKs) and nuclear receptors (NRs). CONCLUSIONS: Although the methods require human intervention and judgment, they can identify the interactions that could occur together or ones that are mutually exclusive. This adds a fourth dimension to interaction network, that of time, and can assist in obtaining concrete predictions consistent with experiments.|Computational Biology/*methods[MESH]|Databases, Protein[MESH]|Estrogen Receptor alpha/metabolism[MESH]|Humans[MESH]|Protein Interaction Mapping/*methods[MESH]|Receptor Protein-Tyrosine Kinases/*metabolism[MESH]|Receptor, ErbB-2/metabolism[MESH]|Receptors, Cytoplasmic and Nuclear/*metabolism[MESH]|Signal Transduction[MESH]|Structural Homology, Protein[MESH] |