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Long-term impact of bronchopulmonary dysplasia on pulmonary function Landry JS; Chan T; Lands L; Menzies DCan Respir J 2011[Sep]; 18 (5): 265-70BACKGROUND: Bronchopulmonary dysplasia (BPD) and the longterm respiratory consequences of prematurity are unfamiliar to adult respirologists and remain under-recognized entities to adult caregivers. In Canada, the incidence of preterm births and its main chronic respiratory complication, BPD, have increased over the past 25 years. OBJECTIVE: To describe the posthospitalization morbidity, medication use, health care use and pulmonary function tests of a large cohort of individuals with preterm birth complicated by BPD. METHODS: A retrospective review of the hospital records of 322 preterm infants with BPD was conducted. Outcome variables were compared across levels of disease severity. Differences between groups were tested with one-way ANOVA for continuous variables and the Mantel-Haenszel chi-squared test for ordinal variables. RESULTS: Outcomes after the initial hospitalization that were associated with the initial severity of BPD were as follows: hospital readmissions in the first two years of life, the presence of developmental delay, forced expiratory volume in 1 s and forced vital capacity on pulmonary function tests in patients between eight and 15 years of age. CONCLUSION: Initial BPD severity was an important predictor of pulmonary function abnormality and health care use during childhood.|Adolescent[MESH]|Attention Deficit Disorder with Hyperactivity/epidemiology[MESH]|Bronchopulmonary Dysplasia/complications/epidemiology/*physiopathology[MESH]|Child[MESH]|Developmental Disabilities/epidemiology[MESH]|Female[MESH]|Follow-Up Studies[MESH]|Hearing Disorders/epidemiology[MESH]|Humans[MESH]|Infant, Newborn[MESH]|Infant, Premature[MESH]|Lung/*physiopathology[MESH]|Male[MESH]|Nervous System Diseases/epidemiology[MESH]|Respiratory Function Tests[MESH]|Retrospective Studies[MESH]|Severity of Illness Index[MESH]|Vision, Low/epidemiology[MESH] |
