Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve Pubget Overpricing |
lüll Posttranscriptional control of X-chromosome dosage compensation Graindorge A; Militti C; Gebauer FWiley Interdiscip Rev RNA 2011[Jul]; 2 (4): 534-45RNA regulation plays a major role in the generation of diversity at the molecular and cellular levels, and furnishes the cell with flexibility potential to adapt to changing environments. Often, the regulation by/of RNA dictates when, where, and how the information encoded in the nucleus is revealed. One example is the regulation of X-chromosome dosage compensation. In Drosophila, differences in X-linked gene dosage between males and females are compensated by the transcriptional upregulation of the single male X chromosome. Mechanisms of alternative splicing and translational control, among others, enforce dosage compensation in males while inhibiting this process in females. In this review, we discuss the posttranscriptional RNA regulatory mechanisms that ensure appropriate dosage compensation in Drosophila, drawing parallels with the mammalian system when appropriate.|*Dosage Compensation, Genetic[MESH]|*RNA Processing, Post-Transcriptional[MESH]|Animals[MESH]|Caenorhabditis elegans/genetics/metabolism[MESH]|DNA-Binding Proteins/genetics/metabolism[MESH]|Drosophila Proteins/genetics/metabolism[MESH]|Drosophila/genetics/metabolism[MESH]|Female[MESH]|Male[MESH]|Mammals/genetics/metabolism[MESH]|Models, Genetic[MESH]|Nuclear Proteins/genetics/metabolism[MESH]|Protein Biosynthesis[MESH]|RNA Splicing[MESH]|RNA-Binding Proteins/genetics/metabolism[MESH]|Transcription Factors/genetics/metabolism[MESH]|X Chromosome/*genetics/*metabolism[MESH] |