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lüll Antioxidant and inflammatory aspects of lipoprotein-associated phospholipase A(2) (Lp-PLA(2)): a review Silva IT; Mello AP; Damasceno NRLipids Health Dis 2011[Sep]; 10 (ä): 170The association of cardiovascular events with Lp-PLA2 has been studied continuously today. The enzyme has been strongly associated with several cardiovascular risk markers and events. Its discovery was directly related to the hydrolysis of the platelet-activating factor and oxidized phospholipids, which are considered protective functions. However, the hydrolysis of bioactive lipids generates lysophospholipids, compounds that have a pro-inflammatory function. Therefore, the evaluation of the distribution of Lp-PLA2 in the lipid fractions emphasized the dual role of the enzyme in the inflammatory process, since the HDL-Lp-PLA2 enzyme contributes to the reduction of atherosclerosis, while LDL-Lp-PLA2 stimulates this process. Recently, it has been verified that diet components and drugs can influence the enzyme activity and concentration. Thus, the effects of these treatments on Lp-PLA2 may represent a new kind of prevention of cardiovascular disease. Therefore, the association of the enzyme with the traditional assessment of cardiovascular risk may help to predict more accurately these diseases.|1-Alkyl-2-acetylglycerophosphocholine Esterase/antagonists & inhibitors/blood/chemistry/*metabolism[MESH]|Animals[MESH]|Anticholesteremic Agents/therapeutic use[MESH]|Antioxidants/*metabolism[MESH]|Atherosclerosis/blood/epidemiology/metabolism/prevention & control[MESH]|Humans[MESH]|Inflammation Mediators/blood/*metabolism[MESH]|Lipoproteins, LDL/blood/metabolism[MESH]|Lysophospholipids/blood/*metabolism[MESH]|Molecular Targeted Therapy[MESH]|Oxidative Stress[MESH]|Risk Factors[MESH] |