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lüll Occipital nerve stimulation with the Bion(R) microstimulator for the treatment of medically refractory chronic cluster headache Strand NH; Trentman TL; Vargas BB; Dodick DWPain Physician 2011[Sep]; 14 (5): 435-40BACKGROUND: Chronic cluster headache is a severely disabling neurological disorder. Evidence from open-label case series suggest that occipital nerve stimulation may be effective for the treatment of chronic cluster headache. OBJECTIVE: To evaluate the effectiveness of a microstimulator for chronic cluster headache. STUDY DESIGN: Prospective, observational feasibility study plus medical record review. SETTINGS: Academic medical center. METHODS: Four patients with medically refractory chronic cluster headache underwent implantation of a unilateral bion microstimulator. In-person follow-up was conducted for 12 months after implantation, and a prospective follow-up chart review was carried out to assess long term outcome. RESULTS: Three of the participants returned their headache diaries for evaluation. The mean duration of chronic cluster headache was 14.3 years (range 3 to 29 years). Pain was predominantly or exclusively retroocular/periocular. One participant demonstrated a positive response (> 50% reduction in cluster headache frequency) at 3 months post-implant, while there were 2 responders at 6 months. At least one of the participants continued to show > 60% reduction in headache frequency at 12 months. A chart review showed that at 58-67 months post-implant, all 3 participants reported continued use and benefit from stimulation. No side-shift in attacks was noted in any participant. Adverse events were limited to 2 participants with neck pain and/or cramping with stimulation at high amplitudes; one required revision for a faulty battery. LIMITATIONS: Small patient population without control group. Not blinded or randomized. CONCLUSION: Unilateral occipital nerve stimulation, using a minimally invasive microstimulator, may be effective for the treatment of medically refractory chronic cluster headache. This benefit may occur immediately after implantation, remain sustained up to 5 years after implantation, and occur despite the anterior location of the pain. Prospective, randomized controlled trials of occipital nerve stimulation in chronic cluster headache should proceed. |Adult[MESH]|Aged[MESH]|Alkadienes/*therapeutic use[MESH]|Cluster Headache/*therapy[MESH]|Electric Stimulation Therapy/*methods[MESH]|Electrodes, Implanted[MESH]|Female[MESH]|Humans[MESH]|Male[MESH]|Middle Aged[MESH]|Pain Measurement[MESH]|Polymers/*therapeutic use[MESH]|Prospective Studies[MESH]|Spinal Nerves/*physiology[MESH]|Treatment Outcome[MESH] |