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Dual protective role of HO-1 in transplanted liver grafts: a review of experimental and clinical studies Wang CF; Wang ZY; Li JYWorld J Gastroenterol 2011[Jul]; 17 (26): 3101-8Liver transplantation is considered as the most effective treatment for end-stage liver disease. However, serious complications still exist, particularly in two aspects: ischemia and subsequent reperfusion of the liver, causing postoperative hepatic dysfunction and even failure; and acute and chronic graft rejections, affecting the allograft survival. Heme oxygenase (HO), a stress-response protein, is believed to exert a protective function on both the development of ischemia-reperfusion injury (IRI) and graft rejection. In this review of current researches on allograft protection, we focused on the HO-1. We conjecture that HO-1 may link these two main factors affecting the prognosis of liver transplantations. In this review, the following aspects were emphasized: the basic biological functions of HO-1, its roles in IRI and allograft rejection, as well as methods to induce HO-1 and the prospects of a therapeutic application of HO-1 in liver transplantation.|*Liver Transplantation[MESH]|Graft Rejection/physiopathology/*prevention & control[MESH]|Graft Survival/*physiology[MESH]|Heme Oxygenase-1/*metabolism/therapeutic use[MESH]|Humans[MESH]|Liver Diseases/*surgery[MESH]|Reperfusion Injury/physiopathology/prevention & control[MESH]|Treatment Outcome[MESH] |
