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Vasculogenic mimicry and mosaic vessels and targeted therapy in renal cell carcinoma Deng JH; Li HZZhongguo Yi Xue Ke Xue Yuan Xue Bao 2011[Aug]; 33 (4): 462-7Renal cell carcinoma is one of the most common malignant tumors of urinary system. The annual incidence rate is approximately 17.9/100 000 populations, and there is a continually rising trend in number of new diagnosis. Metastatic and high-risk renal cell cancer is associated with a poor prognosis and is resistant to traditional chemotherapy and/or radiotherapy. Although cytokine-based therapies (interferon and interleukin-2) have been widely used, their effectiveness remained unsatisfactory due to their low response rates and short survival. Drugs targeting anti-angiogenesis pathways have shown benefits in relapse-free survival. In this review, we introduce the recent advances in the treatment of renal cancer, especially the application of vasculogenic mimicry and mosaic vessels. Although targeted therapies with anti-angiogenic properties have proposed new treatment criteria for advanced renal cell carcinoma, new drugs or new combinations are needed to improve the clinical efficacy and minimize adverse effects.|Carcinoma, Renal Cell/*blood supply/*therapy[MESH]|Humans[MESH]|Kidney Neoplasms/*blood supply/*therapy[MESH] |
