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lüll Consensus statement on the diagnosis, management, and treatment of angioedema mediated by bradykinin Part I Classification, epidemiology, pathophysiology, genetics, clinical symptoms, and diagnosis Caballero T; Baeza ML; Cabanas R; Campos A; Cimbollek S; Gomez-Traseira C; Gonzalez-Quevedo T; Guilarte M; Jurado-Palomo GJ; Larco JI; Lopez-Serrano MC; Lopez-Trascasa M; Marcos C; Munoz-Caro JM; Pedrosa M; Prior N; Rubio M; Sala-Cunill AJ Investig Allergol Clin Immunol 2011[]; 21 (5): 333-47; quiz follow 347BACKGROUND: There are no Spanish guidelines or consensus statement on bradykinin-induced angioedema. AIM: To review the pathophysiology, genetics, and clinical symptoms of the different types of bradykinin-induced angioedema and to draft a consensus statement in light of currently available scientific evidence and the experience of experts. This statement will serve as a guideline to health professionals. METHODS: The consensus was led by the Spanish Study Group on Bradykinin-Induced Angioedema (SGBA), a working group of the Spanish Society of Allergology and Clinical Immunology. A review was conducted of scientific papers on different types of bradykinin-induced angioedema (hereditary and acquired angioedema due to C1 inhibitor deficiency, hereditary angioedema related to estrogens, angioedema induced by angiotensin-converting enzyme inhibitors). Several discussion meetings of the SGBA were held in Madrid to reach the consensus. RESULTS: The pathophysiology, genetics, and clinical symptoms of the different types of angioedema are reviewed. Diagnostic approaches are discussed and the consensus reached is described. CONCLUSIONS: A review of bradykinin-induced angioedema and a consensus on diagnosis are presented.|*Angioedema/classification[MESH]|Bradykinin/*adverse effects/therapeutic use[MESH]|Coronary Vasospasm/*drug therapy[MESH]|Drug Hypersensitivity/diagnosis/epidemiology/genetics/*physiopathology[MESH]|Emergency Medical Services[MESH]|Evidence-Based Medicine[MESH]|Expert Testimony[MESH]|Humans[MESH]|Practice Guidelines as Topic[MESH]|Risk Factors[MESH]|Spain[MESH]|Vasodilator Agents/*adverse effects/therapeutic use[MESH] |