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lüll Nitroimidazoles for the treatment of TB: past, present and future Mukherjee T; Boshoff HFuture Med Chem 2011[Sep]; 3 (11): 1427-54Tuberculosis remains a leading cause of death resulting from an infectious agent, and the spread of multi- and extensively drug-resistant strains of Mycobacterium tuberculosis poses a threat to management of global health. New drugs that effectively shorten the duration of treatment and are active against drug-resistant strains of this pathogen are urgently required to develop effective chemotherapies to combat this disease. Two nitroimidazoles, PA-824 and OPC-67683, are currently in Phase II clinical trials for the treatment of TB and the outcome of these may determine the future directions of drug development for anti-tubercular nitroimidazoles. In this review we summarize the development of these nitroimidazoles and alternative analogs in these series that may offer attractive alternatives to PA-824 and OPC-67683 for further development in the drug-discovery pipeline. Lastly, the potential pitfalls in the development of nitroimidazoles as drugs for TB are discussed.|*Drug Discovery/methods/trends[MESH]|Animals[MESH]|Antitubercular Agents/administration & dosage/chemistry/*therapeutic use[MESH]|Clinical Trials, Phase II as Topic[MESH]|Drug Evaluation, Preclinical[MESH]|Humans[MESH]|Molecular Structure[MESH]|Nitroimidazoles/administration & dosage/chemistry/*therapeutic use[MESH]|Structure-Activity Relationship[MESH]|Tuberculosis, Pulmonary/*drug therapy[MESH] |