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Oligonucleotides decoy to NF-kappaB: becoming a reality?De Stefano DDiscov Med 2011[Aug]; 12 (63): 97-105In the last two decades, frontiers in new drug development are represented by genetic code inhibitors. Nuclear factor-kappaB (NF-kappaB) is a transcription factor playing critical roles in many inflammatory/immune diseases. Decoy oligonucleotides (decoy ONs) epitomize an ideal pharmacological tool to selectively block NF-kappaB activation. Their use is currently being investigated in several chronic inflammatory-based diseases. However, decoy ONs' clinical use is strongly hampered by several issues. Chemical modifications and/or delivery systems have been investigated to overcome some of these limits. This review describes the successful preclinical and clinical applications of decoy ON against NF-kappaB in inflammatory-based diseases.|Animals[MESH]|Humans[MESH]|Inflammation/drug therapy/metabolism[MESH]|Models, Biological[MESH]|NF-kappa B/*antagonists & inhibitors[MESH]|Oligonucleotides/*therapeutic use[MESH] |
