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Review of juxtaglomerular cell tumor with focus on pathobiological aspect Kuroda N; Gotoda H; Ohe C; Mikami S; Inoue K; Nagashima Y; Petersson F; Alvarado-Cabrero I; Pan CC; Hes O; Michal M; Gatalica ZDiagn Pathol 2011[Aug]; 6 (ä): 80Juxtaglomerular cell tumor (JGCT) generally affects adolescents and young adults. The patients experience symptoms related to hypertension and hypokalemia due to renin-secretion by the tumor. Grossly, the tumor is well circumscribed with fibrous capsule and the cut surface shows yellow or gray-tan color with frequent hemorrhage. Histologically, the tumor is composed of monotonous polygonal cells with entrapped normal tubules. Immunohistochemically, tumor cells exhibit a positive reactivity for renin, vimentin and CD34. Ultrastructurally, neoplastic cells contain rhomboid-shaped renin protogranules. Genetically, losses of chromosomes 9 and 11 were frequently observed. Clinically, the majority of tumors showed a benign course, but rare tumors with vascular invasion or metastasis were reported. JGCT is a curable cause of hypertensive disease if it is discovered early and surgically removed, but may cause a fatal outcome usually by a cerebrovascular attack or may cause fetal demise in pregnancy. Additionally, pathologists and urologists need to recognize that this neoplasm in most cases pursues a benign course, but aggressive forms may develop in some cases.|Diagnosis, Differential[MESH]|Humans[MESH]|Juxtaglomerular Apparatus/*pathology/surgery[MESH]|Kidney Neoplasms/epidemiology/genetics/*pathology/surgery[MESH]|Predictive Value of Tests[MESH]|Prognosis[MESH] |
