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  • The use of mouse models to understand and improve cognitive deficits in Down syndrome
  • Das I; Reeves RH
  • Dis Model Mech 2011[Sep]; 4 (5): 596-606
  • Remarkable advances have been made in recent years towards therapeutics for cognitive impairment in individuals with Down syndrome (DS) by using mouse models. In this review, we briefly describe the phenotypes of mouse models that represent outcome targets for drug testing, the behavioral tests used to assess impairments in cognition and the known mechanisms of action of several drugs that are being used in preclinical studies or are likely to be tested in clinical trials. Overlaps in the distribution of targets and in the pathways that are affected by these diverse drugs in the trisomic brain suggest new avenues for DS research and drug development.
  • |*Disease Models, Animal[MESH]
  • |Animals[MESH]
  • |Behavior, Animal[MESH]
  • |Brain/pathology/physiopathology[MESH]
  • |Clinical Trials as Topic[MESH]
  • |Cognition Disorders/*complications/physiopathology[MESH]
  • |Down Syndrome/*complications/drug therapy/physiopathology[MESH]
  • |Humans[MESH]
  • |Mice[MESH]





  • *{{pmid21816951}}
    *<b>[http://www.kidney.de/mlpefetch.php?search=21816951 The use of mouse models to understand and improve cognitive deficits in Down syndrome ]</b> Dis Model Mech 2011; 4(5) ; 596-606 Das I; Reeves RH

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    Dis Model Mech

    596 5.4 2011