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lüll Handpicking epigenetic marks with PHD fingers Musselman CA; Kutateladze TGNucleic Acids Res 2011[Nov]; 39 (21): 9061-71Plant homeodomain (PHD) fingers have emerged as one of the largest families of epigenetic effectors capable of recognizing or 'reading' post-translational histone modifications and unmodified histone tails. These interactions are highly specific and can be modulated by the neighboring epigenetic marks and adjacent effectors. A few PHD fingers have recently been found to also associate with non-histone proteins. In this review, we detail the molecular mechanisms and biological outcomes of the histone and non-histone targeting by PHD fingers. We discuss the significance of crosstalk between the histone modifications and consequences of combinatorial readout for selective recruitment of the PHD finger-containing components of chromatin remodeling and transcriptional complexes.|*Epigenesis, Genetic[MESH]|*Protein Structure, Tertiary[MESH]|Chromatin Assembly and Disassembly[MESH]|Histones/*chemistry/metabolism[MESH]|Homeodomain Proteins/chemistry/metabolism[MESH]|Protein Binding[MESH]|Protein Processing, Post-Translational[MESH]|Transcription, Genetic[MESH] |