Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
free
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
free free
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve Pubget Overpricing |
lüll The role of morphine in regulation of cancer cell growth Gach K; Wyrebska A; Fichna J; Janecka ANaunyn Schmiedebergs Arch Pharmacol 2011[Sep]; 384 (3): 221-30Morphine is considered the "gold standard" for relieving pain and is currently one of the most effective drugs available clinically for the management of severe pain associated with cancer. In addition to its use in the treatment of pain, morphine appears to be important in the regulation of neoplastic tissue. Although morphine acts directly on the central nervous system to relieve pain, its activities on peripheral tissues are responsible for many of the secondary complications. Therefore, understanding the impact, other than pain control, of morphine on cancer treatment is extremely important. The effect of morphine on tumor growth is still contradictory, as both growth-promoting and growth-inhibiting effects have been observed. Accumulating evidence suggests that morphine can affect proliferation and migration of tumor cells as well as angiogenesis. Various signaling pathways have been suggested to be involved in these extra-analgesic effects of morphine. Suppression of immune system by morphine is an additional complication. This review provides an update on the influence of morphine on the growth and migration potential of tumor cells.|Analgesics, Opioid/*pharmacology/therapeutic use[MESH]|Animals[MESH]|Apoptosis/drug effects[MESH]|Cell Line, Tumor[MESH]|Cell Movement/drug effects[MESH]|Cell Proliferation/*drug effects[MESH]|Humans[MESH]|Morphine/*pharmacology/therapeutic use[MESH]|Neoplasm Invasiveness[MESH]|Neoplasms/blood supply/immunology/metabolism/*pathology[MESH]|Neovascularization, Pathologic/chemically induced/pathology[MESH]|Receptors, Opioid/metabolism[MESH] |