Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
 free
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
 free
 free
 
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve
Pubget Overpricing |  
lüll
Systems biology and physical biology of clathrin-mediated endocytosis Ramanan V; Agrawal NJ; Liu J; Engles S; Toy R; Radhakrishnan RIntegr Biol (Camb) 2011[Aug]; 3 (8): 803-15In this review, we describe the application of experimental data and modeling of intracellular endocytic trafficking mechanisms with a focus on the process of clathrin-mediated endocytosis. A detailed parts-list for the protein-protein interactions in clathrin-mediated endocytosis has been available for some time. However, recent experimental, theoretical, and computational tools have proved to be critical in establishing a sequence of events, cooperative dynamics, and energetics of the intracellular process. On the experimental front, total internal reflection fluorescence microscopy, photo-activated localization microscopy, and spinning-disk confocal microscopy have focused on assembly and patterning of endocytic proteins at the membrane, while on the theory front, minimal theoretical models for clathrin nucleation, biophysical models for membrane curvature and bending elasticity, as well as methods from computational structural and systems biology, have proved insightful in describing membrane topologies, curvature mechanisms, and energetics.|*Endocytosis[MESH]|*Systems Biology[MESH]|Animals[MESH]|Anisotropy[MESH]|Biophysics/methods[MESH]|Clathrin/*metabolism[MESH]|Elasticity[MESH]|Endosomes/metabolism[MESH]|Humans[MESH]|Light[MESH]|Microscopy, Confocal/methods[MESH]|Microscopy, Fluorescence/methods[MESH]|Models, Biological[MESH]|Protein Interaction Mapping[MESH]|Software[MESH] |
